abstract：:The effects of Chagas disease on the mammalian circadian system were studied in Trypanosoma cruzi-infected C57-B16J mice. Animals were inoculated with CAI or RA strains of T. cruzi or vehicle, parasitism confirmed by blood specimen visualization and locomotor activity rhythms analyzed by wheel-running recording. RA-st...

journal_title：Chronobiology international

authors： Fernández Alfonso T,Celentano AM,Gonzalez Cappa SM,Golombek DA

更新日期：2003-01-01 00:00:00

abstract：:This study investigates if the serotoninergic system plays a role in chronotoxic effects of the anticancer agent oxaliplatin (l-OHP). Four groups of female rats (120 in total) synchronized with light-dark (12 h:12 h) were treated with: (i) saline, (ii) para-chlorophenylalanine (pCPA, an inhibitor of serotonin biosynth...

journal_title：Chronobiology international

authors： Boughattas NA,Ben Attia M,Ixart G,Lemaigre G,Mechkouri M,Reinberg A

更新日期：2002-11-01 00:00:00

abstract：:The properties of the circadian photoperiodic oscillator have been investigated in detail only in the Japanese quail. While the study of the quail is clearly very important, one cannot simply assume that other species, especially passerines that seem to have a different circadian organization than quail, function the ...

journal_title：Chronobiology international

authors： Singh S,Misra M,Rani S,Kumar V

更新日期：2002-09-01 00:00:00

abstract：:The aim of this study was to examine the effect of the interaction of circamensal and diurnal rhythms in temperature upon the production of maximal voluntary muscle force. Ten eumenorrheic females (mean age: 24 +/- 3 yr mean body mass: 58.4 +/- 6.9 kg) participated in the experiment at both 06:00 and 18:00h at the mid...

journal_title：Chronobiology international

authors： Birch K,Reilly T

更新日期：2002-07-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) or ubiquinone, a redox component of the mitochondrial electron transport chains, is a powerful antioxidant and membrane stabilizer that may prevent cellular damage during myocardial ischemia and reperfusion therapy. Coenzyme Q10 has been used primarily as an adjuvant therapy for some cardiomyopath...

journal_title：Chronobiology international

authors： Reis F,Hermida RC,Souza I,Maldonado J,Tavares P,Fontes-Ribeiro CA,Teixeira HM,Alcobia T,Almeida L,Teixeira F

更新日期：2002-05-01 00:00:00

abstract：:Heat resistance appears to cycle in concert with energy metabolism in continuous culture of the yeast Saccharomyces cerevisiae. To study the mechanism of this oscillation, the authors first examined if heat shock proteins (Hsps) are involved. Neither the protein levels of major Hsps nor the expression of the beta-gala...

journal_title：Chronobiology international

authors： Uno T,Wang J,Mitsui K,Umetani K,Tamura K,Tsurugi K

更新日期：2002-03-01 00:00:00

abstract：:This article reviews the experimental and clinical data that form the basis for the chronotherapy of lung carcinoma, specifically, nonsmall cell lung cancer (NSCLC). Circadian rhythms in cell kinetics, immunological and endocrinological endpoints, and tumor markers are reviewed. Chronopharmacology and chronotolerance ...

journal_title：Chronobiology international

authors： Focan C

更新日期：2002-01-01 00:00:00

abstract：:In 24h studies of bone marrow (BM), circadian stage-dependent variations were demonstrated in the proliferative activity of BM cells from subsets of 35 healthy diurnally active men. On an average, the percentage of total BM cells in deoxyribonucleic acid (DNA) synthesis phase was 188% greater at midday than at midnigh...

journal_title：Chronobiology international

authors： Smaaland R,Sothern RB,Laerum OD,Abrahamsen JF

更新日期：2002-01-01 00:00:00

abstract：:The golden hamster (Mesocricetus auratus) is one of the most frequently used laboratory animals, particularly in chronobiological studies. One reason is its very robust and predictable rhythms, although the question arises whether this is an inbreeding effect or rather is typical for the species. We compared the daily...

journal_title：Chronobiology international

authors： Weinert D,Fritzsche P,Gattermann R

更新日期：2001-11-01 00:00:00

abstract：:The prevalence of delayed sleep phase syndrome (DSPS) has been estimated to be quite low. Although no genetic inheritance pattern has been described, it has been reported that close to 50% of DSPS patients have biological relatives with similar symptoms. A pedigree of one extended family with symptoms suggestive of DS...

journal_title：Chronobiology international

authors： Ancoli-Israel S,Schnierow B,Kelsoe J,Fink R

更新日期：2001-09-01 00:00:00

abstract：:In previous experiments, we found that rats raised in constant light (LL) manifested a more robust circadian rhythm of motor activity in LL and showed longer phase shifts after a light pulse in constant darkness (DD) than chose raised under constant darkness. In addition, we observed that the effects produced by const...

journal_title：Chronobiology international

authors： Canal-Corretger MM,Vilaplana J,Cambras T,Díez-Noguera A

更新日期：2001-07-01 00:00:00

abstract：:Recent studies suggest melatonin, due to its antioxidant and free-radical-scavenging actions, may play a role in the neuroprotection against amyloid, which is implicated in the pathogenesis of Alzheimer's disease (AD). In this study, we determined urinary 6-sulfatoxymelatonin (aMT6s) excretion together with actigraphi...

journal_title：Chronobiology international

authors： Luboshitzky R,Shen-Orr Z,Tzischichinsky O,Maldonado M,Herer P,Lavie P

更新日期：2001-05-01 00:00:00

abstract：:Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/...

journal_title：Chronobiology international

authors： Eide EJ,Virshup DM

更新日期：2001-05-01 00:00:00

abstract：:One proposed hypothesis regarding the etiology of chronic fatigue syndrome (CFS) is that there is a subgroup of patients in which symptom onset is precipitated by a viral infection. If this is indeed true, then one would anticipate a greater incidence of the emergence of CFS symptoms during months when viral infection...

journal_title：Chronobiology international

authors： Jason LA,Taylor RR,Carrico AW

更新日期：2001-03-01 00:00:00

abstract：:Julien-Joseph Virey (1775-1846) held the position of pharmacist-in-chief at the Val-de-Grâce, a military hospital. He was an innovative pharmacist, naturalist, anthropologist, and philosopher and a prolific author. His writings encompassed a wide range of topics, although many of his ideas were sometimes harshly quest...

journal_title：Chronobiology international

authors： Reinberg AE,Lewy H,Smolensky M

更新日期：2001-03-01 00:00:00

abstract：:Serious adverse cardiovascular events, including myocardial infarction, sudden cardiac death, and stroke, frequently result from rupture of atherosclerotic plaques with superimposed thrombosis and exhibit a pronounced circadian rhythmicity, peaking in the morning hours. Two potentially synergistic mechanisms play a pa...

journal_title：Chronobiology international

authors： Aronson D

更新日期：2001-01-01 00:00:00

abstract：:The influence of environmental (extracellular) pH on the sporulation rhythm in Neurospora crassa was investigated for wild-type (frq+) and the mutants chr, frq1, frq7, and frq8. In all mutants, including wild type, the growth rate was found to be influenced strongly by extracellular pH in the range 4-9. On the other h...

journal_title：Chronobiology international

authors： Ruoff P,Behzadi A,Hauglid M,Vinsjevik M,Havås H

更新日期：2000-11-01 00:00:00

abstract：:In this study, we aimed to show how age affects hibernation in the Syrian hamster. Experimentally, we used 30 male animals differing in age. The old animals were 20 months of age and the adults were 8 months of age at the end of the test. The young animals were 3 weeks old at the start of testing and 5 months old at t...

journal_title：Chronobiology international

authors： Terada A,Ibuka N

更新日期：2000-09-01 00:00:00

abstract：:The construction of time-specified reference limits requires systematic sampling in clinical health, particularly for those variables characterized by a circadian rhythm of large amplitude, as it is the case for blood pressure (BP). For the detection of false negatives, tolerance intervals (limits that will include at...

journal_title：Chronobiology international

authors： Fernändez JR,Hermida RC

更新日期：2000-07-01 00:00:00

abstract：:Using both previously published findings and entirely new data, we present evidence in support of the argument that the circadian dysfunction of advancing age in the healthy human is primarily one of failing to transduce the circadian signal from the circadian timing system (CTS) to rhythms "downstream" from the pacem...

journal_title：Chronobiology international

authors： Monk TH,Kupfer DJ

更新日期：2000-05-01 00:00:00

abstract：:In the free-running circadian locomotor activity rhythm of a 7-year-old male owl monkey (Aotus lemurinus griseimembra) kept under constant light and climatic conditions (LL 0.2 lux, 25 degrees C +/- 1 degrees C, 60 +/- 5% relative humidity [RH]), a second rhythm component developed that showed strong relative coordina...

journal_title：Chronobiology international

authors： Erkert HG

更新日期：2000-03-01 00:00:00

abstract：:The ventromedial hypothalamic nucleus (VMH) regulates various autonomic, endocrine, and behavioral activities. These activities show annual changes, and the pineal gland is involved in their adjustment to environmental cues. Therefore, this study investigated whether the VMH belongs to the effector structures of the p...

journal_title：Chronobiology international

authors： Peschke D,Teichmann J,Peschke E

更新日期：2000-01-01 00:00:00

abstract：:The objective of the present study was to evaluate seasonal periodicity in the prevalence of Helicobacter pylori. A prospective study was performed on 1076 consecutive patients who were investigated in our hospital over a 3-year span because of epigastric complaints. Our findings indicate a significant accumulation of...

journal_title：Chronobiology international

authors： Raschka C,Schorr W,Koch HJ

更新日期：1999-11-01 00:00:00

abstract：:In spite of frequent reports that nocturnal asthma results in fatigue and impaired cognitive performance, there exists little objective evidence as to the daytime consequences of this disorder. Treatment studies have established that the symptoms of nocturnal asthma improve with medication intervention, but performanc...

journal_title：Chronobiology international

authors： Bender BG,Annett RD

更新日期：1999-09-01 00:00:00

abstract：:Fourteen ambulatory subjects, varying in their amount of habitual physical activity, were studied for 24 h during a total of 25 "typical" days. Rectal temperature was recorded every 6 minutes, an activity diary was filled in every half hour, and wrist activity and heart rate were monitored every minute. Actimetry and ...

journal_title：Chronobiology international

authors： Waterhouse J,Edwards B,Mugarza J,Flemming R,Minors D,Calbraith D,Williams G,Atkinson G,Reilly T

更新日期：1999-07-01 00:00:00

abstract：:Dysregulation of the system of nitric oxide (NO)-cyclic 3',5'-guanosine monophosphate (cGMP) might be involved in the development of hypertension in transgenic hypertensive TGR(mREN2)27 (TGR) rats. The present study was performed to determine possible differences in the day-night pattern and the urinary excretion rate...

journal_title：Chronobiology international

authors： Globig S,Witte K,Lemmer B

更新日期：1999-05-01 00:00:00

abstract：:The effect of varying the dose-delivery time within a 24 h period (12:12 light-dark cycle) on the immunomodulatory properties of corn oil administered by gavage to 120 B6C3F1 female mice was investigated. Mice, housed in six separate boxes equipped with timers to regulate light onset and offset (staggered by 4 h incre...

journal_title：Chronobiology international

authors： Ratajczak HV,Sothern RB,Dozier MM,Gaworski CL

更新日期：1999-03-01 00:00:00

abstract：:Humans may be subject to seasonal variations, as evidenced by the existence of seasonal affective disorder (SAD) and midwinter insomnia. However, some recent studies have shown that the seasonal variation in the phase of the circadian rhythm is relatively weak in healthy humans. In the present study, evidence is found...

journal_title：Chronobiology international

authors： Van Dongen HP,Kerkhof GA,Souverijn JH

更新日期：1998-11-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) of the hypothalamus controls circadian rhythmicity in mammals (for reviews, see Refs. 33 and 59). Responses modulated by the SCN are numerous and include rhythms in sleep/wake cycles, locomotor, gnawing and general activity, temperature, ingestive behavior, and rhythms of hormonal and...

journal_title：Chronobiology international

authors： LeSauter J,Silver R

更新日期：1998-09-01 00:00:00

abstract：:In a previous report, we showed that the circadian rhythm of cisplatin (cis-diamminedichloroplatinum, CDDP) toxicity in healthy mice was modified by buthionine sulfoximine (BSO), a specific inhibitor of glutathione (GSH) synthesis. In the present study, the effects of BSO on the rhythms of CDDP toxicity and antitumor ...

journal_title：Chronobiology international

authors： Li XM,Filipski E,Lévi F

更新日期：1998-07-01 00:00:00

abstract：:Stress is associated with significant losses in the swine industry. Seasonal changes have been shown to affect stress resistance in several species of animals. In the present study, we examined the effect of two seasons (fall or winter) on plasma insulin, cortisol, and adrenocorticotrophin hormone (ACTH) levels from f...

journal_title：Chronobiology international

authors： Roberts SA,Schaefer AL,Murray AC,Thibault L

更新日期：1998-05-01 00:00:00

abstract：:Time-dependent variations in the vasodilator effects of beta-adrenergic agonists terbutaline (Ter) and dobutamine (Dob) were studied in isolated rings of rat thoracic aorta in both endothelium-intact and endothelium-denuded preparations. Rats were housed in light from 08:00 to 20:00 and in darkness from 20:00 to 08:00...

journal_title：Chronobiology international

authors： Güney HZ,Hodoğlugil U,Uluoğlu C,Görgün CZ,Ercan ZS,Abacioğlu N,Zengil H

更新日期：1998-03-01 00:00:00

abstract：:Various processes associated with mammalian reproduction exhibit circadian rhythms, yet no information is available concerning the presence of rhythmicity in meiosis-the crucial process of the production of sex cells. Following meiosis in cells derived from male mice exposed in vivo to daily light-dark cycles (LD), we...

journal_title：Chronobiology international

authors： Rienstein S,Dotan A,Avivi L,Ashkenazi I

更新日期：1998-01-01 00:00:00

abstract：:The circalunidian-clock hypothesis is a formulation describing the means by which the tide-associated rhythms of intertidal organisms are generated. The postulate was described in a 1995 article in this journal (12:299-310). A recent paper published here (13:153-62) by Prof. Ernest Naylor challenges the validity of th...

journal_title：Chronobiology international

authors： Palmer JD

更新日期：1997-07-01 00:00:00

abstract：:A diary-based instrument-the Social Rhythm Metric (SRM)-was used to assess the level of stability of daily social and behavioral rhythms in a group of 239 healthy subjects (112 male, 127 female) ranging in age from 20 to 89 years. Each subject completed the instrument for two consecutive weeks, which were averaged to ...

journal_title：Chronobiology international

authors： Monk TH,Reynolds CF 3rd,Kupfer DJ,Hoch CC,Carrier J,Houck PR

更新日期：1997-05-01 00:00:00

abstract：:A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the ...

journal_title：Chronobiology international

authors： Redlin U,Mrosovsky N

更新日期：1997-03-01 00:00:00

abstract：:Shiftwork, particularly that including night work, causes disruption of biological rhythms and perturbation of the social and family life that can negatively affect performance efficiency, health, and social relations. Adverse effects can manifest themselves in the short term as sleep disturbances, shiftlag syndrome, ...

journal_title：Chronobiology international

authors： Costa G

更新日期：1997-03-01 00:00:00

abstract：:Visual sensitivity rhythm has been assessed by several authors in animals. It shows an intrinsic circadian rhythm of some retinal mechanisms that could account for fluctuating sensitivity to light during the day in these species. However, very little is known concerning a possible circadian rhythm of visual sensitivit...

journal_title：Chronobiology international

authors： Tassi P,Pins D

更新日期：1997-01-01 00:00:00

abstract：:The objective of this study was to determine in a significant temporal pattern exists in the presentation of sickle cell vaso-occlusive pain crisis (SC-VPC) patients to an emergency department (ED) for treatment. This 28-month retrospective study of ED sickle cell crisis treatment involved 1128 presumably diurnally ac...

journal_title：Chronobiology international

authors： Auvil-Novak SE,Novak RD,el Sanadi N

更新日期：1996-12-01 00:00:00

abstract：:Fourteen healthy subjects have been studied in an isolation unit while living on a 30h "day" (20h awake, 10h asleep) for 14 (solar) days but while aware of real time. Waking activities were sedentary and included reading, watching television, and so forth. Throughout, regular recordings of rectal temperature were made...

journal_title：Chronobiology international

authors： Minors DS,Folkard S,Waterhouse JM

更新日期：1996-10-01 00:00:00